The eye as a biomarker for Alzheimer's disease

JKH Lim; QX Li; Z He; AJ Vingrys; VHY Wong; N Currier; J Mullen; BV Bui; CTO Nguyen

Journal article

The eye as a biomarker for Alzheimer's disease

JKH Lim, QX Li, Z He, AJ Vingrys, VHY Wong, N Currier, J Mullen, BV Bui, CTO Nguyen

Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2016

DOI: 10.3389/fnins.2016.00536

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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading cause of dementia and the number of cases are projected to rise in the next few decades. Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. Though effective, these methods are not widely available due to issues such as the difficulty in acquiring samples, lack of infrastructure or high cost. Given that the eye possesses clear optics and shares many neural and vascular similarities ..

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University of Melbourne Researchers

Qiao-Xin Li Author

Algis Vingrys Author

Bang Bui Author

Christine Nguyen Author

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Grants

Awarded by Biogen

Funding Acknowledgements

CN, BB, AV, JM, (all authors), Samantha Budd Haeberlein, are joint investigators on an Australian Research Council Linkage grant LP160100126. BB is a sole investigator on Australian Research Council Linkage grant FT130100338.